In the context of replacing HCFCs, the alternatives must meet the basic requirement of having zero ozone depleting potential. Developed countries have more or less moved to HFCs from HCFCs and developing countries have started phasing in HFCs. However, Multilateral Fund (MLF) specifically encourages and promotes alternatives that minimise environmental impacts, taking into account globalwarming potential (GWP), and energy efficiency. However, for various sub-sectors, there is no single ‘one-size-fits all’ option to replace HCFCs; each alternative has its own pros and cons and several important issues, particularly relating to safety, need to be addressed.